![]() Serum sodium levels should also be monitored for potential hyponatremia. Lithium must be closely monitored with a narrow therapeutic serum range of 0.8 to 1.2 mEq/L. Nursing Considerations Across the Lifespan ![]() Lithium is indicated in the treatment of manic episodes of bipolar disorder and as a maintenance treatment for individuals with a diagnosis of bipolar disorder. Lithium alters sodium transport in nerve and muscle cells and effects a shift toward intraneuronal metabolism of catecholamines, but the specific biochemical mechanism of lithium action in mania is unknown. Lithium must be closely monitored with a narrow therapeutic range. Lithium was the first medication used to treat this disorder and is sometimes referred to as an anti-mania drug because it can help control the mania that occurs in bipolar disorder. Mood stabilizers are used to treat bipolar affective disorder.
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